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3 Immunohistochemistry of interleukin-1 (IL-1) in the dorsal root ganglion (DRG) and spinal cord (SC) at (A) 5 min (representative value of phase 1) and (B) 35 min (representative value of phase 2) Graph (bottom) represents the number of immunostained cells in the DRG and SC (mean SD)

[6] [7] This discovery was groundbreaking because natural human GLP-1 has a very short half-life it is rapidly degraded by the enzyme dipeptidyl peptidase-4 (DPP-4) within minutes of secretion

In the DECLARE trial [see Clinical Studies (14.3)], serious genital mycotic infections were reported in 55% were reported in 0.4% of placebo-treated patients and 1.3% of dapagliflozin 10 mgtreated patients

Side Effects: Both drugs have similar side effects, including nausea, constipation, and fatigue